首页 / 院系成果 / 成果详情页

Down-Regulated microRNA-34a Expression as a Prognostic Marker for Poor Osteosarcoma in Mice: A Systematic Review and Meta-Analysis 期刊论文

编号：

3d470b92-48ad-4ade-ab2c-7646d4acd269
作者：

Wang, Wenyi#^[1,2]Hu, Shaopu#^[1,2]Chang, Junli^[1,2];Ruan, Hongfeng^[1,2];Zhi, Wenlan^[1,2];Wang, Xiaobo^[1,2];Shi, Qi(施杞)^[1,2]Wang, Yongjun(王拥军)^[1,2]Yang, Yanping(杨燕萍)*^[1,2]
语种：

英文
期刊：

JOURNAL OF CANCER ISSN：1837-9664 2018 年 9 卷 22 期 (4179 - 4186)
收录：
关键词：

microRNA-34a osteosarcoma prognosis meta-analysis mice
摘要：

Background: In children and adolescents, osteosarcomais the most common malignant bone tumor with a high mortality rate. New therapeutic strategies are urgent to be explored. Studies have proven thatmicroRNAs( miRNAs) in malignant tumors often appear dysregulation, this provides a direction for exploring the new therapeutic strategies for cancers. The aimof thismeta-analysis is to summarize and analyze whethermicroRNA-34a(miRNA-34a) could be a prognostic marker for osteosarcoma in mice.
Methods: We searchedPubMed, Web of Science, Embase, Wan Fang Database, China Knowledge Resource Integrated Database, VIP Database, and SinoMedsince their initiation date to January 24, 2018. After screening based on inclusion and exclusion criteria, eight articles were included for the final analysis.
Results: Our results showed that tumor volume and tumor weight were inhibited by restoring the down-regulated expression of miRNA-34a in the xenograft mouse models.
Conclusions: Down-regulated miRNA-34a expression is a prognostic marker for poor osteosarcoma. We should be more committed to investigate the clinical significance of miRNA-34a in osteosarcoma patients.
推荐引用方式
GB/T 7714：

Wang Wenyi,Hu Shaopu,Chang Junli, et al. Down-Regulated microRNA-34a Expression as a Prognostic Marker for Poor Osteosarcoma in Mice: A Systematic Review and Meta-Analysis [J].JOURNAL OF CANCER,2018,9(22):4179-4186.
APA：

Wang Wenyi,Hu Shaopu,Chang Junli,Ruan Hongfeng,&Yang Yanping.(2018).Down-Regulated microRNA-34a Expression as a Prognostic Marker for Poor Osteosarcoma in Mice: A Systematic Review and Meta-Analysis .JOURNAL OF CANCER,9(22):4179-4186.
MLA：

Wang Wenyi, et al. "Down-Regulated microRNA-34a Expression as a Prognostic Marker for Poor Osteosarcoma in Mice: A Systematic Review and Meta-Analysis" .JOURNAL OF CANCER 9,22(2018):4179-4186.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：58  下载次数：0

分享到：

浏览次数：58

下载次数：0

打印次数：0