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Antifungal Cyclic Peptides from Psammosilene tunicoides  期刊论文  

  • 编号:
    3cecc189-faeb-4a78-bcbd-aa3f47cda7c4
  • 作者:
    Tian, Junmian#[1]Shen, Yunheng*[1]Yang, Xianwen[1,2];Liang, Shuang(梁爽)[3,4]Shan, Lei[1];Li, Huiliang[1];Liu, Runhui[1];Zhang, Weidong[1,3];
  • 语种:
    英文
  • 期刊:
    JOURNAL OF NATURAL PRODUCTS ISSN:0163-3864 2010 年 73 卷 12 期 (1987 - 1992) ; DEC
  • 收录:
  • 摘要:

    Three new cyclic peptides, tunicyclins B-D, and a known cyclic peptide, psammosilenin B, were isolated from the root of Psammosilene tunicoides. The structures of new cyclic peptides were elucidated by extensive NMR and MS analysis. Tunicyclin B contains an unusual alpha,beta-dehydrotryptophan (Delta(Z)-Trp) residue, previously reported from marine sponges and bacteria. Tunicyclin D showed a broad spectrum of antifungal activity against Candida albicans (SC5314), Candida albicans (Y0109), Candida tropicalis, Candida parapsilosis, and Cryptococcus neoformans (BLS 108) with MIC80 values of 4.0, 16.0, 0.25, 1.0, and 1.0 mu g mL(-1), respectively.

  • 推荐引用方式
    GB/T 7714:
    Tian Junmian,Shen Yunheng,Yang Xianwen, et al. Antifungal Cyclic Peptides from Psammosilene tunicoides [J].JOURNAL OF NATURAL PRODUCTS,2010,73(12):1987-1992.
  • APA:
    Tian Junmian,Shen Yunheng,Yang Xianwen,Liang Shuang,&Zhang Weidong.(2010).Antifungal Cyclic Peptides from Psammosilene tunicoides .JOURNAL OF NATURAL PRODUCTS,73(12):1987-1992.
  • MLA:
    Tian Junmian, et al. "Antifungal Cyclic Peptides from Psammosilene tunicoides" .JOURNAL OF NATURAL PRODUCTS 73,12(2010):1987-1992.
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