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microRNA-497 inhibits invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor-A 期刊论文

编号：

2d1ca871-0fc6-4975-9cb8-ff579eeab835
作者：

Qiu, Yanyan(邱艳艳)#^[1]Yu, Hui(于卉)#^[1]Shi, Xiaojing(石晓静)#^[1]Xu, Ke(徐可)^[2]Tang, Qingfeng(汤庆丰)^[2]Liang, Bo^[1];Hu, Songjiao^[1];Bao, Yijie(包益洁)^[1]Xu, Jianhua(许建华)^[2]Cai, Jie(蔡杰)^[1]Peng, Wen(彭文)^[3]Cao, Qin(曹勤)*^[4]Yin, Peihao(殷佩浩)*^[1,2]
语种：

英文
期刊：

CELL PROLIFERATION ISSN：0960-7722 2016 年 49 卷 1 期 (69 - 78) ; FEB
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摘要：

ObjectivesmicroRNAs (miRNAs), are non-coding RNAs that regulate gene expression, and are involved in tumour development. The aim of this study was to investigate microRNA-497 (miR-497) expression and its role in development of colorectal cancer (CRC).
Materials and methodsRT-PCR was performed to detect expression of miR-497 in CRC cell lines (HCT8, LOVO, Ls-174, HCT116 and HT29) and in clinical cancer specimens. To further understand its role, we restored expression of miR-497 in the HCT116 cell line by transfection with miR-497 mimics or inhibitors. Effects of miR-497 on cell proliferation, migration and invasion of targets were also determined both in vitro and in vivo.
ResultsmiR-497 expression decreased in 34 CRC tissues compared to non-tumour tissues and in tumour cell lines. Overexpression of miR-497 did not inhibit cancer cell growth but suppressed metastasis and invasion both in vitro and in vivo. Vascular endothelial growth factor-A (VEGF-A) was confirmed to be a target of miR-497. Furthermore, we found overexpression of miR-497 altered expression of key molecules of the VEGF-A/ERK/MMP-9 signalling pathway.
ConclusionsThus our results provide evidence that miR-497 might function as a metastasis suppressor in CRC. Targeting miR-497 may provide a strategy for blocking its metastasis.
推荐引用方式
GB/T 7714：

Qiu Yanyan,Yu Hui,Shi Xiaojing, et al. microRNA-497 inhibits invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor-A [J].CELL PROLIFERATION,2016,49(1):69-78.
APA：

Qiu Yanyan,Yu Hui,Shi Xiaojing,Xu Ke,&Yin Peihao.(2016).microRNA-497 inhibits invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor-A .CELL PROLIFERATION,49(1):69-78.
MLA：

Qiu Yanyan, et al. "microRNA-497 inhibits invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor-A" .CELL PROLIFERATION 49,1(2016):69-78.
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