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The angiotensin-I converting enzyme gene I/D variation contributes to end-stage renal disease risk in Chinese patients with type 2 diabetes receiving hemodialysis 期刊论文

编号：

28a1e194-4105-4b46-9b88-c2669bdc7b0d
作者：

Lu, Ming(陆明)#^[1]Zhang, Jianzhong#^[2]Li, Ming#^[3]Ge, Xiaoxu^[3];Dai, Xu^[4];Zhao, Jiao^[4];Fu, Mingzhou^[4];Wang, Tao^[4];Fang, Xiyao^[4];Li, Can^[3];Zhang, Rong^[3];Zhao, Weijing^[3];Zheng, Taishan^[3];Wang, Feng^[5];Yu, Ming(喻明)^[1]Lei, Tao(雷涛)^[1]Wang, Niansong^[5];Bao, Yuqian^[3];Liu, Limei*^[3]Liu, Yanjun^[6];Jia, Weiping^[3];
语种：

英文
期刊：

MOLECULAR AND CELLULAR BIOCHEMISTRY ISSN：0300-8177 2016 年 422 卷 1-2 期 (181 - 188) ; NOV
收录：
关键词：

Angiotensin-I converting enzyme (ACE) I/D variation Type 2 diabetes mellitus (T2DM) End-stage renal disease (ESRD) Hemodialysis
摘要：

Whether the DD genotype of the angiotensin-I converting enzyme (ACE) I/D variation contributes to end-stage renal disease (ESRD) risk in type 2 diabetes mellitus (T2DM) remains controversial. Differences in study design, case and control definition, sample size and ethnicity may contribute to the discrepancies reported in association studies. We performed a case-control study to evaluate the association of the ACE I/D variation with ESRD risk in Chinese patients with T2DM receiving hemodialysis and analyzed the genotype-phenotype interaction. Unrelated Chinese patients (n = 432) were classified into the non-diabetic nephropathy (DN) control group (n = 222, duration of diabetes > 10 years, no signs of renal involvement) and the DN-ESRD group (n = 210; ESRD due to T2DM, receiving hemodialysis). Polymerase chain reaction was used to genotype ACE I/D for all 432 subjects. The frequencies of the ID + DD genotypes were higher in the DN-ESRD group than non-DN control group (65.2 vs. 50.9 %; adjusted OR 1.98 (95 % CI, 1.31-3.00; P = 0.001). In the DN-ESRD group, the DD genotypic subgroup had significantly elevated HbA1c and diastolic blood pressure (DBP) compared to the II subgroup (both P < 0.05). The DD genotype of the ACE I/D variation may be associated with more elevated blood pressure and HbA1c, and therefore may predict the development, progression and severity of DN-ESRD in Chinese patients with T2DM undergoing hemodialysis.
推荐引用方式
GB/T 7714：

Lu Ming,Zhang Jianzhong,Li Ming, et al. The angiotensin-I converting enzyme gene I/D variation contributes to end-stage renal disease risk in Chinese patients with type 2 diabetes receiving hemodialysis [J].MOLECULAR AND CELLULAR BIOCHEMISTRY,2016,422(1-2):181-188.
APA：

Lu Ming,Zhang Jianzhong,Li Ming,Ge Xiaoxu,&Jia Weiping.(2016).The angiotensin-I converting enzyme gene I/D variation contributes to end-stage renal disease risk in Chinese patients with type 2 diabetes receiving hemodialysis .MOLECULAR AND CELLULAR BIOCHEMISTRY,422(1-2):181-188.
MLA：

Lu Ming, et al. "The angiotensin-I converting enzyme gene I/D variation contributes to end-stage renal disease risk in Chinese patients with type 2 diabetes receiving hemodialysis" .MOLECULAR AND CELLULAR BIOCHEMISTRY 422,1-2(2016):181-188.
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