首页 / 院系成果 / 成果详情页

Reduced mir-29b-3p expression up-regulate CDK6 and contributes to IgA nephropathy 期刊论文

编号：

2467c86f-30f6-46e3-b6dd-6bb9b5c6e5ff
作者：

Xing, LiNa#^[1]Wang, Hao(王浩)^[1]Yin, PeiHao(殷佩浩)^[1]Liu, YuJun(刘育军)^[1]Chi, YangFeng(池杨峰)^[1]Wang, YunMan^[1]Peng, Wen(彭文)*^[1]
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE ISSN：1940-5901 2014 年 7 卷 12 期 (5275 - 5281)
收录：
关键词：

MicroRNA IgA nephropathy CDK6 p65 phosphorylation
摘要：

IgA nephropathy (IgAN) is the most common glomerulonephritis and the etiology of which is complex and multiple, and the pathological damage of IgAN is diversified. MicroRNA is a kind of gene expression suppressor and recently, researchers have found that microRNAs may play an important role in the pathogenesis of IgAN. Herein, we found that miR-29b-3p not miR-29a or miR-29c was significantly down regulated in IgAN patients' renal tissues. Predicted by bioinformatics tools and confirmed by dual luciferase assay and western blot, we found that the expression of CDK6 was repressed by miR-29b-3p directly. Subsequently, we found that miR-29b-3p down-regulation caused CDK6 overexpression can promote NF-kappa B signal by phosphorylating p65 which may enhance inflammation during IgAN pathogenesis.
推荐引用方式
GB/T 7714：

Xing Li-Na,Wang Hao,Yin Pei-Hao, et al. Reduced mir-29b-3p expression up-regulate CDK6 and contributes to IgA nephropathy [J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2014,7(12):5275-5281.
APA：

Xing Li-Na,Wang Hao,Yin Pei-Hao,Liu Yu-Jun,&Peng Wen.(2014).Reduced mir-29b-3p expression up-regulate CDK6 and contributes to IgA nephropathy .INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,7(12):5275-5281.
MLA：

Xing Li-Na, et al. "Reduced mir-29b-3p expression up-regulate CDK6 and contributes to IgA nephropathy" .INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 7,12(2014):5275-5281.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：11  下载次数：0

分享到：

浏览次数：11

下载次数：0

打印次数：0