The advance of medical technology allows people extending the life, and the promotion of material life standards allows people thinking of a better life. Accordingly, general public or medical institutions gradually emphasize health-related quality of life. Moreover, the increasing medical expenses in past years result in unbalance medical finance that effectively controlling the increasing utilization of medical ecology becomes a critical issue. Selecting the general public in Shanghai as the research samples for the questionnaire survey, total 500 copies of questionnaire are distributed, from which invalid and incomplete ones are deducted for 421 valid copies of questionnaire, with the retrieval rate 84%. The research results show remarkably negative correlations between 1.health-related quality of life and medical expenses, 2.health-related quality of life and number of medical visits, as well as 3.health-related quality of life and number of hospitalization. According to the results, suggestions are proposed, expecting to achieve the goal of promoting the citizens' health-related quality of life.