首页 / 院系成果 / 成果详情页

Neomerane-type sesquiterpenoids from Valeriana officinalis var. latifolia 期刊论文

编号：

15945589-9874-45b6-88d0-d39a47278b93
作者：

Han, ZhuZhen(韩竹箴)#^[1,2]Zu, XianPeng#^[1]Wang, JinXin^[1];Li, HuiLiang*^[1]Chen, BingYang^[1];Liu, QingXin^[1];Hu, XianQing^[1];Yan, ZhaoHui^[1];Zhang, WeiDong*^[1,2,3]
语种：

英文
期刊：

TETRAHEDRON ISSN：0040-4020 2014 年 70 卷 4 期 (962 - 966) ; JAN 28
收录：
关键词：

Valeriana officinalis var latifolia Valerianaceae Valeneomerins A, B, C, and D Neomerane-type sesquiterpenoids Neuroprotective activities
摘要：

Valeneomerins A-D, two new neomerane-type sesquiterpenoids and two new nor-sesquiterpenoids, were isolated from the roots of Valeriana officinalis var. latifolia. Among them, valeneomerin A (1) was identified as a sesquiterpenoid with an unprecedented 15,3-lactone loop while valeneomerin C (3) and valeneomerin D (4) were determined to be nor-sesquiterpenoids with a new 15-reductive neomeranetype carbon skeleton. Their structures were elucidated by detailed spectroscopic analysis and Cu K alpha X-ray crystallography. Compounds 1, 2, and 4 exhibited significant neuroprotective effects against H2O2 induced oxidative stress in SH-SY5Y cells with viability of 49.8, 40.9, and 44.6% each at 50 mu M, respectively, in contrast to positive control (catechin, 50 mu M) with viability of 32.6%. (C) 2013 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Han Zhu-Zhen,Zu Xian-Peng,Wang Jin-Xin, et al. Neomerane-type sesquiterpenoids from Valeriana officinalis var. latifolia [J].TETRAHEDRON,2014,70(4):962-966.
APA：

Han Zhu-Zhen,Zu Xian-Peng,Wang Jin-Xin,Li Hui-Liang,&Zhang Wei-Dong.(2014).Neomerane-type sesquiterpenoids from Valeriana officinalis var. latifolia .TETRAHEDRON,70(4):962-966.
MLA：

Han Zhu-Zhen, et al. "Neomerane-type sesquiterpenoids from Valeriana officinalis var. latifolia" .TETRAHEDRON 70,4(2014):962-966.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：3  下载次数：0

分享到：

浏览次数：3

下载次数：0

打印次数：0