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Comparison between Chinese Herbal Medicines and Conventional Therapy in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial 期刊论文

编号：

0dc9295c-8519-471b-86bd-a42931114930
作者：

Li, Xiuhui^[1];Zhang, Xi^[2];Ding, Jianbo^[1];Xu, Yi^[3];Wei, Dan^[4];Tian, Yimei^[1];Chen, Wei^[5];Huang, Jihan^[6];Wen, Tao#*^[7]Li, Shuangjie#^[8]
语种：

英文
期刊：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE ISSN：1741-427X 2014 年 2014 卷
收录：
摘要：

Background. This study was made to evaluate the efficacy of Chinese herbal medicines, Reduning injection, and a traditional Chinese medicine (TCM) granule, in patients with severe hand, foot, and mouth disease (HFMD) by conducting a prospective, controlled, and randomized trial. Methods. 355 severe HFMD patients were randomly assigned to receive conventional therapy alone, Reduning injection plus conventional therapy, or TCM enema plus conventional therapy for 7-10 days. Results. There was no significant difference in the incidence of major complications between the groups. Median time to fever clearance was 20 hours (95% CI: 6.0-25.0) for conventional therapy recipients, 18 hours (95% CI: 4.0-24.0) for Reduning combination-treated patients, and 6 hours (95% CI: 4.0-16.0) for TCM combination-treated patients. Only the difference in time to fever clearance between TCM combination group and conventional group reached statistical significance (P = 0.048). Reduning combination group showed a significant reduction in sedative administration compared with conventional therapy group (P = 0.008). No HFMD-related death and no important adverse events were observed. Conclusions. Reduning injection plus conventional therapy significantly reduced the concomitant use of sedatives, which may help decrease HFMD-related neurologic complications in children. TCM effectively reduced time to fever clearance and may become a complementary therapy for relieving the symptoms of severe HFMD.
推荐引用方式
GB/T 7714：

Li Xiuhui,Zhang Xi,Ding Jianbo, et al. Comparison between Chinese Herbal Medicines and Conventional Therapy in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial [J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,2014.
APA：

Li Xiuhui,Zhang Xi,Ding Jianbo,Xu Yi,&Li Shuangjie.(2014).Comparison between Chinese Herbal Medicines and Conventional Therapy in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial .EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014.
MLA：

Li Xiuhui, et al. "Comparison between Chinese Herbal Medicines and Conventional Therapy in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial" .EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2014(2014).
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