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Folate receptor targeted bufalin/beta-cyclodextrin supramolecular inclusion complex for enhanced solubility and anti-tumor efficiency of bufalin 期刊论文

编号：

0b87a9ed-afb1-4cb9-b705-6fdae4cf3ff3
作者：

Zou Aihua#*^[1,2]Zhao Xiaotong#^[1,2]Handge, Ulrich A.^[5];Garamus, Vasil M.^[6];WillumeitRoemer, Regine^[6];Peihao, Yin(殷佩浩)*^[3,4]
语种：

英文
期刊：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS ISSN：0928-4931 2017 年 78 卷 (609 - 618) ; SEP 1
收录：
关键词：

Bufalin beta-cydodextrin Inclusion complex Folic acid Drug delivery
摘要：

Bufalin (BF), a traditional Chinese medicine, exhibited inhibitory activities against a broad spectrum of tumor cells. The present study elaborates that bufalin was successfully encapsulated into the cavity of beta-cyclodextrin (beta-CD), which was determined by Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (H-1 NMR), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The best reaction mole ratio of BF/beta-CD was 1:5. The solubilities of bufalin in water and phosphate buffer solution (pH = 7.4) were increased up to 24 and 34 times after encapsulated into the cavity of S-CD respectively. The inclusion efficiency (IE) and drug loading (DL) of bufalin in the inclusion complex were (94.22 +/- 0.85)% and (14.11 +/- 0.20)%, respectively. Then beta-CD conjugated with folic acid (FA) were further prepared and employed to improve the anti-tumor efficacy of inclusion complex. The in vitro dissolution and solubility study showed better values of inclusion complex and FA targeted inclusion complex than that of pure BF. Cytotoxicity experiments by using HCT116 cell line revealed that the antitumor efficiency of bufalin were enhanced more than two folds in the presence of beta-CD and folate conjugated beta-CD (FA-PEI-beta-CD), which demonstrated the potential application of beta-CD (FA-9EI-beta-CD) as delivery vehicles of bufalin for antitumor therapy. (C) 2017 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Zou Aihua,Zhao Xiaotong,Handge Ulrich A., et al. Folate receptor targeted bufalin/beta-cyclodextrin supramolecular inclusion complex for enhanced solubility and anti-tumor efficiency of bufalin [J].MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,78:609-618.
APA：

Zou Aihua,Zhao Xiaotong,Handge Ulrich A.,Garamus Vasil M.,&Peihao Yin.(2017).Folate receptor targeted bufalin/beta-cyclodextrin supramolecular inclusion complex for enhanced solubility and anti-tumor efficiency of bufalin .MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,78:609-618.
MLA：

Zou Aihua, et al. "Folate receptor targeted bufalin/beta-cyclodextrin supramolecular inclusion complex for enhanced solubility and anti-tumor efficiency of bufalin" .MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 78(2017):609-618.
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