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Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor 期刊论文

编号：

030a57f6-6c74-439a-b614-797e4bfa8098
作者：

Bao, Xiaoze#^[1]Wei, Shiqiang^[1];Qian, Xingkai^[2]Qu, Jingping^[1];Wang, Baomin*^[1]Zou, Liwei*^[2]Ge, Guangbo^[2]
语种：

英文
期刊：

ORGANIC LETTERS ISSN：1523-7060 2018 年 20 卷 11 期 (3394 - 3398) ; JUN 1
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摘要：

A catalytic asymmetric [3 + 2] cyclization of novel 4-isothiocyanato pyrazolones and isatin-derived ketimines was developed, delivering a wide range of intriguing dispirotriheterocyclic products in high yield with excellent diastereoselectivity and enantioselectivity. A chiral sulfoxide derivative of this dispirocyclic product was identified to be a promising hit of the human carboxylesterase 1 inhibitor, and the significant difference of the activity between two enantiomers emphasized the importance of this asymmetric process.
推荐引用方式
GB/T 7714：

Bao Xiaoze,Wei Shiqiang,Qian Xingkai, et al. Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor [J].ORGANIC LETTERS,2018,20(11):3394-3398.
APA：

Bao Xiaoze,Wei Shiqiang,Qian Xingkai,Qu Jingping,&Ge Guangbo.(2018).Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor .ORGANIC LETTERS,20(11):3394-3398.
MLA：

Bao Xiaoze, et al. "Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor" .ORGANIC LETTERS 20,11(2018):3394-3398.
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